Randy Niedz is a Research Geneticist at the United States Horticultural Research Laboratory, Ft. Pierce, Florida. He has a PhD in Plant Breeding and Genetics from Michigan State University (USA). His USDA research assignment is citrus breeding and horticulture using in vitro technologies. Currently, Niedz is developing conceptual and experimental design approaches for complex in vitro systems, with a particular emphasis on mineral nutrition. He developed the linear programming algorithm that solved the long-standing and vexing problem of ion confounding, which is nearly universal in experiments across the entire scientific landscape (agriculture, medicine, ecology, chemistry, …). The algorithm is required for designing the types of experiments capable of quantifying ion-specific effects. To utilize the algorithm, Niedz developed a conceptual and experimental framework for statistically valid experimentation with mineral nutrient ions. The framework requires concepts that are counter-intuitive and not normally considered or incorporated in experiments to determine ion-specific effects. These concepts profoundly impact the methods and assumptions of the last 100 years on how to conduct research with ionic systems in diverse fields ranging from physical chemistry to fertilization to culture media formulations. For plant tissue culture, these concepts represent a new approach for understanding mineral nutrient effects. Further, Niedz has developed a geometric-based framework for in vitro culture experimentation that, unlike recipe-based experimentation, generalizes to the broader questions of the influence of media components and environmental factors on in vitro growth and development. He is an Associate Editor for the In Vitro Society’s journal, In Vitro Cellular and Developmental Biology, and an Academic Editor for the journal PLoS ONE.